Nonprofit funding cardiovascular research, educating the public, and promoting cardiac care in the US.
This week has upended expectations for drugs that lower lipoprotein(a). Novartis has said its pelacarsen shot cut Lp(a) but has not reduced heart attacks, strokes or deaths. Other Lp(a) and inflammation candidates have also failed or been halted, while unrelated mid‑stage trials on aging clocks and COPD have reported positive signals.
Danone has filed a lawsuit in Manhattan federal court alleging Chobani inflates protein claims on multiple-serving tubs of Chobani 20G Protein, a rival to Danone’s Oikos Pro. The case underscores how protein claims are shaping competition in the US amid rising GLP-1 weight-loss drug use. Danone says Chobani’s labeling misleads consumers and undercuts its pricing. Chobani rejects the allegations; analysts note concerns over capacity and competitive dynamics.
Heat waves have intensified health risks, worsening heart and kidney conditions, triggering heat exhaustion, and contributing to inflammatory issues. Experts urge hydration, shade, and cooling measures as high temperatures persist and climate change drives higher heat.
A wave of hot weather has triggered new warnings about how heat changes physiology and mood. Experts say heat triggers vascular changes, dehydration risk, and cognitive and mood shifts, with women facing particular risks. Readers are advised to stay hydrated, avoid peak heat, and monitor vulnerable groups.
Preliminary medical examiner findings indicate an aortic dissection linked to artery hardening has caused the death of a sitting senator. Reports describe sudden chest or back pain and rapid onset of life-threatening symptoms; speedy treatment is critical.
Graham has died at 71 after a suspected brief illness. Medical examiner findings indicate an aortic dissection linked to arteriosclerosis as the likely cause; official cause will follow toxicology and microscopic tests. Social media claims of foul play are unfounded according to preliminary reports. Authorities have noted FBI assistance at Graham’s home.
The FDA has approved Lipfendra, Merck’s oral PCSK9 inhibitor, to lower LDL cholesterol in patients on statins. Trials show ~55-60% LDL reductions; the pill will be sold at about $315/month and must be taken on an empty stomach. Analysts see potential peak sales in the billions as injectable rivals face competition and access barriers.
New observational data suggests Shingrix vaccination in older adults is associated with lower cardiovascular risk and reduced dementia incidence over multi-year follow-ups. Studies compare Shingrix to Zostavax and find reductions in heart disease, stroke, and dementia, with stronger signals in men for heart outcomes.
A seven-year study of about 41,000 adults in South Korea finds that modest weekend catch-up sleep—about 1 hour 27 minutes—reduces the risk of high blood pressure by up to 9%, with larger benefits for physically inactive individuals. Excessive weekend sleep (>4 hours) may offset gains. Findings were presented at the European Society of Cardiology congress in Munich.