The organ that coordinates thought, movement and the body’s systems
England has authorised Enhertu for routine NHS use for HER2‑low metastatic breast cancer, ensuring access for about 1,000 women annually. The decision follows a previous rejection over cost‑effectiveness and builds on a deal between NICE and drug makers AstraZeneca and Daiichi Sankyo. Scotland has already provided access since 2023.
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A multi-country Latin American trial has found that a two-year, supervised lifestyle program improves cognition, memory, and processing speed in adults aged 60-77 at risk of dementia. The programme combines exercise, diet, brain training, and social activity, and outperforms standard health guidance.
A body of studies is showing that a blood marker called p-tau217 can forecast an elevated risk of cognitive impairment in healthy older adults years before symptoms appear. The evidence is not yet clinical-ready, but it is guiding trials that aim to slow or prevent Alzheimer’s disease and is being tested in Scotland’s primary care setting.
International researchers find inherited genetics influence how cancers evolve after DNA damage, affecting tumour growth and mutation patterns. The Edinburgh-led work, published in Nature, underlines implications for screening, diagnosis and personalised treatment across populations.
A UK study across 18 cities shows a rise in e-scooter-related injuries among under-16s and adults, with limb, head and facial injuries most common. Helmet use remains very low. Researchers urge clearer public health messaging and tighter private-e-scooter regulations as trials continue.
Prichard Colón has died at 33 after a career hallmarked by a 2015 coma following blows to the head during a fight with Terrell Williams. He remains 16-0 before that bout; the incident triggered lawsuits and sparking renewed focus on safety in boxing.
Recent reporting aggregates findings that mentally stimulating jobs may lower dementia risk, with evidence that handwriting enhances memory and cognitive function. Expert commentary highlights spatial processing, practice in challenging tasks, and the benefits of social interaction in maintaining brain health.
Stanford researchers have transplanted human brain organoids into mice with cortex-depleted brains, creating a model that links human tissue with mouse neural circuits. The work, reported in Nature, shows human cells wiring into mouse brain tissue and drawing attention to ethical oversight and limitations in translating to human disease.