NFL team based in Nashville, AFC South
The 49ers have trimmed to a 53-man roster ahead of their season opener in Australia against the Rams. They trade for veteran interior lineman Jarrett Patterson, add depth at guard and center, and place several players on IR or PUP as they prepare for Week 1.
Jed York, principal owner of the San Francisco 49ers, has pleaded no contest to misdemeanor charges after an Ohio arrest related to prostitution and criminal tools. The NFL will review under the personal conduct policy. The case centers on a so-called online prostitution ad in East Palestine, Ohio.
The Los Angeles Rams have added two-time Defensive Player of the Year Myles Garrett and Aaron Donald returns from retirement, forming a fearsome pass-rush duo alongside Matthew Stafford as they pursue a second Super Bowl at SoFi Stadium.
This week has seen several medical research and regulatory developments. Insilico Medicine has reported that its experimental drug rentosertib changed blood‑protein patterns that aging clocks read as three to four years younger in a small trial. Stanford teams have published studies showing they can grow hindbrain neurons separately and implant human cortical organoids into mice. The US health department has appointed permanent directors for three FDA centers.
Tennessee Titans and Philadelphia Eagles players faced extreme heat at Nissan Stadium, with turf readings around 157F (69C). Players cooled cleats with water; several instances of cleat melting were reported. Teams adjusted travel plans and equipment as heat drove on-field tactics and debate over grass vs. turf.
Unbeaten teams Kansas City and Minnesota maintain 4-0 records as they win on Sunday. Raiders push Chiefs hard, with a late turnover sealing the game; Maye bounces back for New England after a rough stretch.
Lane Johnson has announced his retirement after 14 NFL seasons with the Philadelphia Eagles, saying his personal and family priorities have changed and that it is critical for him to focus on his mental health. The move follows previous openness about anxiety and depression and comes after a season marked by personal absences.