Public research university in London; member of the University of London; secular, historically inclusive
This week has upended expectations for drugs that lower lipoprotein(a). Novartis has said its pelacarsen shot cut Lp(a) but has not reduced heart attacks, strokes or deaths. Other Lp(a) and inflammation candidates have also failed or been halted, while unrelated mid‑stage trials on aging clocks and COPD have reported positive signals.
A glacial collapse on 26 August has produced a torrent of water, mud and debris that has killed more than 1,410 people and left at least 5,651 missing across Nepal and Tibet. Rescuers have recovered bodies, are searching hydropower tunnels and remote villages, and are racing to manage two barrier lakes whose overflow threatens fresh flooding and access to victims.
The UN General Assembly has endorsed a non-binding move to shift from the Mercator projection to the Equal Earth map to better reflect continental sizes. The vote saw 164 members in favour with the United States abstaining or opposing; several countries express concerns about disputed territories and implications for regional shading.
The United Nations General Assembly has backed an African-led campaign to replace the Mercator map with equal-area projections like Equal Earth, aiming to correct long-standing distortions that have exaggerated the North and underestimated Africa. The resolution is non-binding and urges governments, schools, and tech firms to adopt more accurate maps where size matters.
Robinhood has announced a 10% headcount reduction, affecting about 290 employees, while insisting the business has never been stronger. The move aims to flatten the organization and boost performance as markets show resilience and volume trends improve. The restructuring includes closing some open roles and is expected to incur about $20-28 million in costs.
A set of recent reports cover long Covid rehabilitation, a Parkinson’s diagnosis for Bruce Foxton of The Jam, and Lyme disease campaigning by a Scottish MSP. Also covered are ulcerative colitis coupled with PSC in a Birmingham mother and ongoing chronic illness advocacy in media.
Europe endures a record-breaking heatwave as red heat alerts spread. Authorities warn health and infrastructure face strain while experts link extreme temperatures to climate change. UK, France, Spain and other nations are deploying measures as temperatures push past past records.
Heat waves have intensified health risks, worsening heart and kidney conditions, triggering heat exhaustion, and contributing to inflammatory issues. Experts urge hydration, shade, and cooling measures as high temperatures persist and climate change drives higher heat.
A historic heatwave has swept across Europe, setting temperature records and stressing infrastructure and health systems. Scientists say climate change has doubled the odds of such events, with millions affected as cities grapple with heat-related disruptions and rising energy demand.
Public Health France has recorded 5,764 excess deaths between 17 June and 2 July during an exceptional June heatwave, the highest heat-related excess mortality since 2003. France recorded 21,674 deaths against 15,910 expected; two-thirds of the excess were people aged 75 and older and more than half occurred between 25–27 June.
Financial markets are pricing in the political shift toward a Burnham-led government, with mortgage costs sensitive to fiscal signals. Housing policy is expected to intensify, with calls for a major council-house building programme and tighter rental regulation. Homeowners, buyers and landlords should watch mortgage rate trajectories as markets interpret the new government’s fiscal discipline and spending plans.
A University College London study finds blanket smartphone bans in English schools are seen as punitive by students, with potential negative consequences. The government has introduced a country-wide ban, while researchers warn that such policies may erode trust and fail to address online harms.
AI analysis of 1,722 Scottish heart-trial scans has found that higher density in torso muscles correlates with an 85% lower death risk and a 58% lower risk of heart attack over 10 years. Researchers say muscle quality, not just size, matters; routine scans could guide prevention.
The US Supreme Court has upheld Idaho and West Virginia laws that bar transgender girls from girls' sports, ruling those bans survive Title IX and equal-protection challenges. The decision preserves similar statutes in roughly two dozen states, hands conservative groups a legal lever, and shifts the next fights to state courts, school boards and athletic bodies.
A wave of hot weather has triggered new warnings about how heat changes physiology and mood. Experts say heat triggers vascular changes, dehydration risk, and cognitive and mood shifts, with women facing particular risks. Readers are advised to stay hydrated, avoid peak heat, and monitor vulnerable groups.
A body of studies is showing that a blood marker called p-tau217 can forecast an elevated risk of cognitive impairment in healthy older adults years before symptoms appear. The evidence is not yet clinical-ready, but it is guiding trials that aim to slow or prevent Alzheimer’s disease and is being tested in Scotland’s primary care setting.
A Taiwan study finds that when one spouse develops dementia, the other is more likely to receive the same diagnosis. Relative risk is 74% higher for women and 69% for men, with five-year absolute risks of 6.5% and 9.2% respectively.
A SpaceX Falcon 9 upper stage has struck the Moon near Einstein Crater at about 5,400 mph, carving a new crater and launching a dust plume. South Korea’s Danuri orbiter has photographed the site and released images. NASA’s Lunar Reconnaissance Orbiter is scheduled to image the impact next week while scientists begin analysing ejecta and crater formation.
Labour has moved into a polling lead amid a flurry of policy announcements by Prime Minister Andy Burnham and ongoing investigations surrounding Reform UK leader Nigel Farage. Multiple polls show Labour ahead or tied with Reform, with regional results highlighting gains in Greater Manchester.
A wave of heat and wildfires across Europe and beyond has accelerated, prompting evacuations and sparking political debate on climate policy. Readers are updated on the latest developments, including shifting opinions, policy responses, and the urgent need for adaptation alongside emission cuts.
UK parents Maisie and Josh traveled with their unborn son Theo to Texas for a groundbreaking in-womb procedure to repair complex gastroschisis. The trial, led by foetal and paediatric surgeons, aims to shift treatment before birth. Theo was delivered healthy in Texas and is doing remarkably well; if successful, the UK could offer the procedure to more patients.
Moderna has won FDA approval for its mRNA flu vaccine mFlusiva for adults 50–64 and accelerated approval for those 65 and older. The decision follows a contentious review earlier this year, a unanimous advisory panel recommendation in June and political disputes inside US health agencies over mRNA vaccines. Retail availability is expected in coming weeks.
A wave of studies finds that AI analysis of mammograms can identify cardiovascular risks in women, including hypertension, coronary heart disease and stroke, alongside breast cancer screening. Researchers say mammograms could become a dual-purpose tool for early cardiovascular risk detection, prompting earlier intervention.
Queues to reach Snowdon’s summit have grown amid hot weather and rising visitor numbers. Videos show bottlenecks at the trig point, with wardens urging patience and safety. Discussions focus on safety, access, and inclusivity in Britain’s outdoors.
The UK has established an AI partnership with Ukraine to access the Avengers AI Lab database. The goal is to train models that strengthen national security and protect critical infrastructure, with pilots at defence sites and potential rollouts to airports, prisons, railways and energy facilities.
The NHS has launched a program to send self‑testing HPV kits to eligible women aged 30–65 who have missed cervical screening appointments. The at‑home swabs test for high‑risk HPV; negative results lead to in‑person follow‑ups. The phased rollout aims to boost screening uptake and support the 2040 elimination target.
A series of UK meadow projects shows biodiversity recovering where farmers cut hay annually rather than reseeding or ploughing. From Norfolk to the Cotswolds, fields host diverse wildflowers, insects and birds, highlighting nature-friendly farming as a viable path for resilience.
A large UK Biobank study finds hormone therapy use is associated with a lower risk of dementia, including Alzheimer’s. Benefits vary by age at initiation and genetic factors; observational data limits causal conclusions.
The FDA has approved daraxonrasib (Rasonque), a once-daily pill from Revolution Medicines, for adults with metastatic pancreatic cancer who have received prior therapy or cannot take combination chemotherapy. A 500‑patient trial has shown median survival of 13.2 months versus 6.7 months for chemotherapy; a 30‑day supply will cost about $39,800 and expanded access has already treated thousands.
UK researchers have developed nitinol-based super-elastic cranial springs for severe craniosynostosis, enabling less invasive skull reshaping in children. Rory Potter becomes the first patient to receive the customized springs, with follow-up showing rapid recovery and a reduced need for future surgery. The approach combines CT-guided modelling with bespoke devices at Great Ormond Street Hospital and UCL.
El Niño has strengthened toward historic levels, with NOAA and other forecasters projecting a 75% chance of a record-breaking event in late 2026. The phenomenon is driving higher global temperatures, shifting rainfall, and fueling droughts and floods across regions. Governments warn households to prepare for potential disruptions and to stock essentials.
The 2025 Pisa results indicate Scotland, Wales and Northern Ireland trail England in reading and maths, with science rankings mixed. England leads on science, while Welsh and Scottish scores drop further behind, prompting calls for reform. The OECD notes a global decline in reading and warns of digital distractions affecting performance.